Mebeverine Tablet Uses, Side Effects, Dosage and Precautions (2025)

Antispasmodics, such as mebeverine hydrochloride, are a type of medicine. It is used to relieve abdominal pain and cramps caused by digestive disorders like IBS. It works by relaxing the muscles in the intestinal wall, easing discomfort and improving bowel movement regularity.

• This is an anticholinergic drug.
• Mebeverine is available in the form of tablets or slow-release capsules (also called modified release).
• Colofac, Colofac IBS, and Aurobeverine are all brand names for mebeverine.
• If you have Irritable bowel syndrome, you can take mebeverine mixed with ispaghula husk (brand name Fybogel Mebeverine) to relieve constipation.

What are the Benefits and Uses of Mebeverine?

Mebeverine is used to treat painful digestive issues caused by bowel spasms and inflammatory conditions.

Conditions Mebeverine Helps Treat

• Irritable Bowel Syndrome (IBS)
• Spastic colitis
• Spastic constipation
• Colon inflammation
• Mucous colitis

Secondary Uses of Mebeverine

• Helps relieve constipation when used with ispaghula husk
• May be prescribed in other cases of bowel irritation or inflammation

How Does Mebeverine Work?

Mebeverine acts directly on the muscles of the intestinal wall to reduce spasms and cramping.

By relaxing the smooth muscles of the gut, it prevents painful contractions without affecting normal bowel movements. As an anticholinergic agent, it blocks certain nerve signals that cause intestinal spasms.

Dosage Instructions for Mebeverine

Always use this medication exactly as directed by your doctor. Do not change the dosage without consulting your healthcare provider.

How to take Mebeverine?

• This drug is believed to have an anaesthetic effect by directly acting on the smooth muscles of the gastrointestinal tract.
• It's prescribed for irritable bowel syndrome, and the dosage varies depending on the form of the medication-pills, capsules, or liquid.
• Standard-release tablets (135MG): The normal dosage is one tablet, which should be taken three times a day.
• Slow-release capsules (200mg): The normal dose is one tablet, which should be taken two times a day.

What Should I Do If I Miss a Dose?

• It is necessary to take the missed dose as soon as possible.
• If your next scheduled dose is approaching, it is better to skip the skipped dose.
• To make up for a missed dose, do not take extra medication.

What happens if an Overdose?

• Overdosing on Mebeverine can be harmful and requires the patient should consult a doctor immediately.

Common overdose symptoms may include:

• Dizziness
• Confusion
• Restlessness

In severe cases, gastric lavage (stomach wash) may be needed.

What are the Side Effects of Mebeverine?

Side effects are usually mild but can vary between individuals. Always monitor how your body reacts and consult a doctor if symptoms persist.

Common Side Effects

• Nausea
• Vomiting
• Dizziness
• Headache
• Indigestion or bloating

Serious but Rare Side Effects

• Allergic skin reactions (rash, itching, swelling)
• Shortness of breathing (very rare)
• Rash
• Heartburn

If you have any of these serious symptoms, see your doctor right away. If you encounter any side effects from Mebeverine, try to prevent them.

Precautions and Warnings Before Taking Mebeverine

Before taking Mebeverine talk with your doctor if you are allergic to it or any other medications and any medical history like:

• Liver disease
• Kidney disease
• Stomach ulcers
• Any abdominal problems

Who should avoid this medicine

Pregnancy

Pregnant women do not take this medicine unless it is absolutely required. Before taking this drug, speak to your doctor about all of the complications and benefits.

Breastfeeding

• This drug should be avoided by women who are breastfeeding, unless absolutely necessary.
• Consult your doctor before taking this medication to understand all potential risks and benefits.

Kidney Disease

• This drug should be used with caution in patients with kidney disease.
• There is an increased risk of serious side effects in such cases.
• Depending on the patient's condition, kidney function may need to be closely monitored.
• Dosage adjustments or an alternative medication may be required for safe treatment.

Acute Porphyria

• This drug is not approved for use in patients with acute porphyria.
• Using it may worsen the patient's condition.
• Depending on the patient's health, a suitable alternative medication should be considered.

Are There Any Age Restrictions for Using Mebeverine?

• The drug should only be used if prescribed to children below the age of 10 or if absolutely necessary.
• Only children over the age of ten may be given this medicine.

Possible Interactions with Other Medications

Drug interactions can affect how Mebeverine works or increase the risk of side effects.

• Always let your doctor know about any medications or supplements you are currently taking.
• Use caution when combining it with other anticholinergic or gastrointestinal drugs.

No major interactions are common, but it's important to follow professional advice for safe usage.

How Should Mebeverine Be Stored?

Proper storage ensures the effectiveness and safety of the medicine.

• Mainly, the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
• Direct contact with heat, air, and light may damage your medicines.
• The exposure of medicine may cause some harmful effects.
• The medicine must be kept in a safe place and out of children's reach.

Improper storage can degrade the medication, reducing its effectiveness or causing harm.

Mebeverine vs. Dicyclomine

References

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